Thermo Fisher Scientific DMPK Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DMPK protein. Suitable for research use in muscle and nerve tissue studies. Supplied as liquid, unconjugated form at 0.1 mg/mL concentration. Store at 4°C short term or -20°C long term.
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- pk
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DMPK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640632 |
Product Specific Information
Immunogen sequence:
LGVFAYEMFY GQTPFYADST AETYGKIVHY KEHLSLPLVD EGVPEEARDF IQRLLCPPET RLGRGGAGDF RTHPFFFGLD WDGLRDSVPP FTPDFEGATD TCNFDLVE
Antigen sequence identity:
- Mouse: 86%
- Rat: 86%
Target Information
DMPK is a serine/threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are characteristic of myotonic dystrophy.
The encoded protein interacts with members of the Rho family of small GTPases, and its substrates include myogenin, the beta-subunit of L-type calcium channels, and phospholemman.
The 3′ untranslated region of this gene contains 5–37 copies of a CTG trinucleotide repeat. Expansion to 50–5,000 copies causes myotonic dystrophy type I, with severity increasing with repeat number. Repeat expansion is associated with chromatin condensation that disrupts gene expression in this region.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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