Thermo Fisher Scientific DMPK Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DMPK if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DMPK,uniProtId:Q09013-9,ncbiNodeId:9606,antigenRange:264-371,antigenLength:629,antigenImageFileName:PA5-52627_DMPK_Q09013-9_Rabbit.svg,antigenImageFileNamePDP:PA5-52627_DMPK_Q09013-9_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640632

Product Specific Information

Immunogen sequence: LGVFAYEMFY GQTPFYADST AETYGKIVHY KEHLSLPLVD EGVPEEARDF IQRLLCPPET RLGRGGAGDF RTHPFFFGLD WDGLRDSVPP FTPDFEGATD TCNFDLVE

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.

Target Information

DMPK is a serine/threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are a characteristic of myotonic dystrophy. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3` untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.