Thermo Fisher Scientific ABHD3 Polyclonal Antibody
ABHD3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. Human에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(40% glycerol) 버퍼에 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ABHD3. Recombinant protein control fragment (Product #RP-90347). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637557 |
Product Specific Information
Immunogen sequence:
KKPQLVTGGE SFSRFLQDHC PVVTETYYPT VWCWEGRGQT LLRPFITSKP PVQYRNELIK TADGGQISLD WFDNDNSTCY MDASTRPTIL LLPGLTGTSK ESYILHMIHL SEELGYRCVV FNNRGVAGEN LLTPRTYCCA NTEDLE
- Highest antigen sequence identity to orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
The α/β hydrolase superfamily comprises diverse members involved in key biochemical processes and associated with various diseases. Despite unrelated sequences and different substrates, they share a canonical α/β hydrolase fold with an eight-stranded parallel α/β structure and a catalytic triad (histidine, acid, nucleophile).
Members of this superfamily are often drug targets for conditions such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders.
The ABHD (α/β hydrolase domain containing) gene subfamily includes 15 mostly uncharacterized members, typically utilizing a serine nucleophile forming the G-X-S-X-G nucleophile elbow.
- ABHD1: Metabolizes smoking xenobiotics
- ABHD2: Involved in atherosclerosis development
- ABHD3: 409 amino acid single-pass type II membrane protein
- ABHD4: Participates in NAE (N-acyl ethanolamine) synthesis pathway
- ABHD5: Mutations cause Chanarin-Dorfman syndrome
- ABDH6: May play a role in nervous system metabolism and signaling
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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