Thermo Fisher Scientific CaMKII gamma Polyclonal Antibody, Biotin

Applications and Tested Dilutions

Product Specifications

Target Information

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin binding and autophosphorylation. It is involved in dendritic spine and synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, it plays a structural role in actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments independently of kinase activity. This structural function is essential for proper targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity, enabling long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, it promotes dendritic arborization, while in mature neurons, it supports dendritic remodeling. It also participates in skeletal muscle modulation in response to exercise and regulates Ca(2+) transport and release in slow- and fast-twitch muscles through phosphorylation of triadin and phospholamban.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.