Thermo Fisher Scientific Phospho-NFATC1 (Ser172) Polyclonal Antibody
NFATC1 단백질의 Ser172 인산화 상태를 특이적으로 검출하는 폴리클로날 항체로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 사람, 생쥐, 랫트 반응성. 고순도 정제 및 안정적 PBS/glycerol 저장용액 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-NFATC1 (Ser172) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NFATC1 (Accession O95644), corresponding to amino acid residues around phosphorylated Ser172 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817417 |
Product Specific Information
This antibody detects endogenous levels of NFAT2 only when phosphorylated at Ser172.
Target Information
The NFATC1 gene encodes a component of the nuclear factor of activated T cells (NFAT) DNA-binding transcription complex. This complex includes a cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT family proteins play a central role in inducible gene transcription during immune responses. NFATC1 acts as a major molecular target for immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified, each potentially regulating different cytokine genes.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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