Thermo Fisher Scientific LIMP2 Polyclonal Antibody
LIMP2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. WB와 IHC에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 2-8°C에서 보관하며 장기 보관 시 -20°C 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the center of human LIMP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156197 |
Product Specific Information
Despite its predicted molecular weight, LIMP2 often migrates at 80–85 kDa in SDS-PAGE.
A suggested positive control is human skeletal muscle tissue lysate.
PA5-20540 can be used with blocking peptide PEP-0660.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with risk for atherosclerosis.
SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded C-terminal cytoplasmic domain is almost completely different.
SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI.
Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes.
Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor.
In addition, SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, with the SR-BII isoform mediating selective transfer of lipid between HDL and cells.
The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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