Thermo Fisher Scientific CCBL1 Polyclonal Antibody
Thermo Fisher Scientific의 CCBL1 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot 및 IHC(P)에 적합합니다. 합성 펩타이드 기반 면역원으로 제작된 Rabbit IgG 폴리클로날 항체입니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KYAT1 (Accession Q16773), corresponding to amino acid residues S326–L376 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815661 |
Product Specific Information
Antibody detects endogenous levels of total CCBL1/KAT1.
Target Information
Kynurenine aminotransferases KAT I, KAT II, and KAT III belong to the class-I pyridoxal-phosphate-dependent aminotransferase family.
KAT I is a cytoplasmic protein involved in glutamine catabolism and catalyzes the transamination of L-kynurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan.
Kynurenic acid is involved in synaptic transmission and has been implicated in neurological disorders such as schizophrenia and Huntington’s disease.
KAT I also functions in the metabolism of cysteine conjugates in halogenated alkenes and alkanes to form reactive metabolites.
KAT I has three isoforms:
- Isoform 1: Full-length protein
- Isoform 2: Lacks amino acids 68–117
- Isoform 3: Lacks amino acids 251–422
Based on sequence similarity, KAT I is thought to function as a homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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