Thermo Fisher Scientific CCBL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CCBL1/KAT1.

Target Information

Kynurenine aminotransferases KAT I, KAT II, and KAT III belong to the class-I pyridoxal-phosphate-dependent aminotransferase family.
KAT I is a cytoplasmic protein involved in glutamine catabolism and catalyzes the transamination of L-kynurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan.
Kynurenic acid is involved in synaptic transmission and has been implicated in neurological disorders such as schizophrenia and Huntington’s disease.
KAT I also functions in the metabolism of cysteine conjugates in halogenated alkenes and alkanes to form reactive metabolites.
KAT I has three isoforms:

1. Isoform 1: Full-length protein
2. Isoform 2: Lacks amino acids 68–117
3. Isoform 3: Lacks amino acids 251–422

Based on sequence similarity, KAT I is thought to function as a homodimer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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