Thermo Fisher Scientific DAAM1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total DAAM1.

Target Information

DAAM1 is a diaphanous-related formin first identified as a Disheveled-binding protein crucial for the planar cell polarity pathway in Xenopus. Like other formins, DAAM1 directs nucleation and elongation of new actin filaments via its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and gastrulation regulation. DAAM1 binds both the Wnt receptor-associated protein Disheveled and the GTP-bound RhoA, increasing the GTP-bound form population in cells. The protein exists in an autoinhibited state through intramolecular interactions between its amino-terminal GBD and carboxyl-terminal DAD domains. Structurally, DAAM1 includes a GTPase-binding domain (GBD), diaphanous inhibitory domain (DID), coiled-coil region, FH1, FH2, and C-terminal diaphanous auto-regulatory domain (DAD). In humans, the DAAM1 gene is mapped to chromosome 14q23.1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.