Thermo Fisher Scientific HDAC8 Monoclonal Antibody (OTI9F2), TrueMAB
HDAC8 단백질을 인식하는 Mouse monoclonal antibody로 Human, Mouse, Rat 시료에 반응합니다. Western blot에 최적화되어 있으며, 동결건조 형태로 제공됩니다. PBS 완충액(8% trehalose)으로 안정화되어 장기 보관이 용이합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9F2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–243 of human HDAC8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20 °C, Avoid freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
In cells, DNA associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling, regulated by histone acetylation and deacetylation, plays a key role in transcriptional regulation.
Histone acetylation increases accessibility to transcription factors, while deacetylation is linked to transcriptional silencing.
HDAC8 is a mammalian histone deacetylase localized in the nucleus, sharing homology with other HDACs but differing in tissue distribution. It is involved in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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