Thermo Fisher Scientific SFRP4 Polyclonal Antibody
SFRP4 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 시료에 반응합니다. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다. Wnt 신호 조절 연구 및 암·대사 질환 관련 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SFRP4. Recombinant protein control fragment: Product # RP-88742 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647185 |
Product Specific Information
Immunogen sequence:
RHMPWNITRM PNHLHHSTQE NAILAIEQYE ELVDVNCSAV LRFFLCAMYA PICTLEFLHD PIKPCKSVCQ RARDDCEPLM KMYNHSWPES LACDELPVYD RGVCISPEAI VTDLPEDVKW IDITPDMMVQ ERPLDVDCKR
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 96%
Target Information
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the extracellular domain of Frizzled proteins used for Wnt binding.
Unlike Frizzled proteins, sFRPs lack transmembrane and intracellular domains, functioning instead as soluble modulators of the Wnt signaling pathway by directly binding Wnt proteins and inhibiting receptor interaction and signaling.
sFRP4 is widely expressed in embryonic and adult tissues, acting as:
- A circulating antiangiogenic and proapoptotic factor
- An inhibitor of insulin secretion
- A suppressor of tumor growth and metastasis through Wnt pathway disruption
Downregulation or absence of circulating sFRP4 correlates with progression of cancers such as ovarian, endometrial, prostate, and lung.
Upregulation is linked to glucose metabolism deterioration in type 2 diabetes and suppression of keratinocyte hyperproliferation in psoriasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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