Thermo Fisher Scientific EXD1 Monoclonal Antibody (OTI5B5), TrueMAB
EXD1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, ICC/IF, Flow Cytometry에 적합합니다. HEK293T 세포에서 발현된 full-length 인간 EXD1 단백질을 면역원으로 제작되었습니다. 동결건조 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B5 |
| Immunogen | Full length human recombinant protein of human EXD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process represses transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. This process governs methylation and subsequent repression of transposable elements, which is essential for germline integrity. The PET complex is required during the secondary piRNA metabolic process for PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. Within the PET complex, EXD1 likely functions as an RNA adapter and is considered an inactive exonuclease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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