Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (rBP53-12)

Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (rBP53-12)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Does not react with Mouse or Rat.

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide deprivation. Upon activation, p53 induces transcription of genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain. Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells, contributing to anticancer activity. It is also linked to aging, oxidative stress, and learning deficits due to altered LTP. Normal cells express low levels of p53, but transformed cells show high expression, contributing to malignancy. Mutations in TP53 disrupt DNA binding and tumor suppression, and germline mutations are linked to Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.