Thermo Fisher Scientific TK2 Polyclonal Antibody
Rabbit polyclonal antibody against human TK2 for IHC (paraffin) applications. Recognizes recombinant TK2 protein with high specificity. Suitable for mitochondrial DNA metabolism research. Supplied as liquid, 0.4 mg/mL, store at 4°C short term or -20°C ...
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TK2 Polyclonal Antibody
Applications
Tested Application & Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648496 |
Product Specific Information
Immunogen sequence:
YVVLSEWFDW ILRNMDVSVD LIVYLRTNPE TCYQRLKKRC REEEKVIPLE YLEAIHHLHE EWLIKGSLFP MAAPVLVIEA DHHMERMLEL FEQNRD
Sequence identity to orthologs:
- Mouse: 81%
- Rat: 81%
Target Information
Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, as well as antiviral and anticancer nucleoside analogs. Both recombinant and native forms exhibit broad substrate specificity and complex kinetics, suggesting a role in activation of chemotherapeutic nucleoside analogs.
Highest expression levels are found in testis and ovary. TK2 and deoxyguanosine kinase (DGK) provide the main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis through the salvage pathway. Mutations in these kinases are associated with mitochondrial DNA depletion, indicating their importance in maintaining balanced mitochondrial dNTP pools.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.