Thermo Fisher Scientific RETN Monoclonal Antibody (5E8)
인간 Resistin(RETN)을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot 및 ELISA에 적합. GST 태그가 결합된 full-length recombinant 단백질을 면역원으로 사용. PBS buffer에 보존, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5E8 |
| Immunogen | RETN (NP_065148, 20–106 a.a.) full-length recombinant protein with GST tag (MW of GST: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
TLCSMEEAIN ERIQEVAGSL IFRAISSIGL ECQSVTSRGD LATCPRGFAV TGCTCGSACG SWDVRAETTC HCQCAGMDWT GARCCRV*
Target Information
Adipose tissue acts as an energy reserve and produces various physiologically important proteins including LPL, leptin, Acrp30, perilipin, and resistin.
Resistin (also known as Adipocyte Secreted Factor, ADSF, and FIZZ3) is secreted specifically by adipocytes. It is involved in paracrine signaling and may play a role in type 2 diabetes.
In obese, diabetic mice, serum resistin levels are elevated, antagonizing insulin action and inducing insulin resistance and glucose intolerance.
Resistin gene expression requires C/EBP alpha and is modulated by coactivators CBP and p300 through histone acetylation at the promoter region. PPAR gamma and RXR ligands downregulate resistin expression in adipocytes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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