Thermo Fisher Scientific RAD18 Monoclonal Antibody (3H7)
RAD18 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody(3H7)입니다. Western blot, IHC, ICC, ELISA에 적합하며, 인간 및 랫트 시료에 반응합니다. 고순도 친화 크로마토그래피 정제, PBS 버퍼 보존, 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3H7 |
| Immunogen | RAD18 (NP_064550, 332 a.a. ~ 430 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EKEIDEIHSK YRKKHKSEFQ LLVDQARKGY KKIAGMSQKT VTITKEDEST EKLSSVCMGQ EDNMTSVTNH FSQSKLDSPE ELEPDREEDS SSCIDIQEV
Target Information
Human Rad18 (hRad18) is a homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair, particularly in gap-filling of a daughter strand during replication of damaged DNA. The Rad6–Rad18 interaction is essential at an early step of lesion bypass. In vivo, Rad18 forms a tight complex with Rad6 through a conserved ring-finger motif. The Rad18–Rad6 complex binds to damaged DNA sites, followed by degradation of stalled replication components via the ubiquitin-conjugating activity of Rad6.
Human RAD18 maps to chromosome 3p24–25, a region often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene encodes a 495 amino acid protein with a predicted molecular weight of 56 kDa and is ubiquitously expressed in various tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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