Thermo Fisher Scientific alpha-1 Antitrypsin Monoclonal Antibody (TMF1#4B5)
Human 대상 alpha-1 Antitrypsin 단백질을 인식하는 mouse monoclonal antibody. Western blot, ICC/IF, IP 등 다양한 응용 가능. Protein A로 정제된 5 mg/mL 액상 형태로 제공되며, 냉장 또는 -20°C 장기 보관 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TMF1#4B5 |
| Immunogen | Purified human alpha-1 Antitrypsin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Refrigerated at 2–8°C for up to 6 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154174 |
Product Specific Information
- MIA1101 targets Alpha1-Antitrypsin in IP applications and shows reactivity with human samples.
- The immunogen is purified human alpha-1 Antitrypsin.
- Detects Alpha1-Antitrypsin (~46 kDa predicted molecular weight).
- Formerly sold as a Seradyn product.
Target Information
Alpha-1 Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
Deficiency of alpha-1-AT is associated with chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress in newborns.
Elevated levels occur as an acute phase response to tissue necrosis and inflammation, and are observed in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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