Thermo Fisher Scientific Caspase 13 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunohistochemistry (IHC)

10 µg/mL

-

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 15 amino acid peptide near the amino terminus of bovine Caspase-13 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Caspase 13,uniProtId:O75601-1,ncbiNodeId:9913,antigenRange:1,antigenLength:377,antigenImageFileName:PA5-19949_Caspase_13_O75601-1_Rabbit.svg,antigenImageFileNamePDP:PA5-19949_Caspase_13_O75601-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Ion-exchange chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152616

Product Specific Information

In Western blot applications, this antibody detects a band at ~43kDa.

A suggested positive control is HL60 cell lysate.

PA5-19949 can be used with blocking peptide PEP-0074.

The immunogen is located within amino acids 80 - 130 of Caspase-13.

Target Information

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.