Thermo Fisher Scientific PCDHGA5 Polyclonal Antibody

Thermo Fisher Scientific PCDHGA5 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: U87-MG, IMR32, and SK-N-AS cells
• Predicted reactivity: Mouse (87%), Rat (85%), Chimpanzee (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.
The gamma gene cluster includes 22 genes divided into 3 subfamilies:

• Subfamily A: 12 genes
• Subfamily B: 7 genes and 2 pseudogenes
• Subfamily C: 3 genes

The tandem array of 22 large, variable region exons are followed by a constant region containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region.
These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

Usage Notice

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.