Thermo Fisher Scientific GCAP1 Polyclonal Antibody
Thermo Fisher Scientific의 GCAP1 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 항체입니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, 고순도의 Protein A 정제 및 안정적 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human GCAP1 (amino acids 51–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Guanylate cyclase-activating protein (GCAP1) is a Ca²⁺-binding protein that enhances cGMP synthesis in photoreceptors. Mammalian GCAPs share over 90% similarity, consisting of 201–205 amino acids with three conserved Ca²⁺-binding sites. The GUCA1A gene (GCAP1) is expressed solely in the retina. Mutations such as Tyr99→Cys and Pro50→Leu have been linked to cone dystrophy and variable retinal phenotypes. The mutant proteins retain cyclase activation ability but show reduced thermal stability and increased protease sensitivity, potentially contributing to retinal cell degeneration.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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