Thermo Fisher Scientific MADD Polyclonal Antibody
MADD 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도 친화 크로마토그래피 정제 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MADD (Accession Q8WXG6), corresponding to amino acid residues I758–L808 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850661 |
Product Specific Information
Antibody detects endogenous levels of total MADD.
Target Information
Tumor necrosis factor receptor 1 (TNFR1) contains a death receptor domain that mediates interactions involved in downstream signaling of TNF.
MADD (mitogen activated protein (MAP)-kinase activating death domain protein) associates with the death domain of TNFR1 through its own C-terminal death domain, which is critical for TNFR1 signal generation.
Overexpression of MADD activates MAP kinases (ERK and JNK) and induces phosphorylation of cytosolic phospholipase A2, linking TNF signaling to MAP kinase activation and arachidonic acid release.
MADD shares 98% homology with DENN (differentially expressed in neoplasmic vs. normal cells), a JNK3 substrate involved in hypoxia and stress-induced intracellular signaling.
MADD also shows 93% sequence conservation with a GDP/GTP exchange protein, Rab3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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