Thermo Fisher Scientific BRCC3 Polyclonal Antibody
BRCC3 단백질을 검출하기 위한 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 고품질 항체. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | 2.5 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 2 publications |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the amino terminus of human BRCC36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154606 |
Product Specific Information
- Suggested positive control: MCF7 cell lysate
- PA5-20426 can be used with blocking peptide PEP-0543
Target Information
BRCC36 forms a holoenzyme complex with BRCA1, BRCA2, RAD51, and BRCC45, possessing ubiquitin E3 ligase activity.
Aberrant BRCC36 levels are detected in sporadic breast tumors.
Depletion of BRCC36 or BRCC45 increases sensitivity to ionizing radiation and causes G2/M checkpoint defects, suggesting BRCC36 enhances cellular survival following DNA damage.
BRCC36 is essential for BRCA1 phosphorylation and nuclear foci formation after ionizing radiation, making it a potential target for treating radiation-resistant breast tumors.
At least two isoforms of BRCC36 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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