Thermo Fisher Scientific DFF45 Monoclonal Antibody (OTI5C4), TrueMAB
DFF45 단클론 항체(OTI5C4)는 인간 ICAD 단백질을 인식하는 Mouse IgG1 항체입니다. Western blot과 Immunocytochemistry에 적합하며, 동결건조 형태로 제공됩니다. PBS buffer(8% trehalose)로 안정화되어 있으며, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2500–1:5000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C4 |
| Immunogen | Full length human recombinant protein of human DFFA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ICAD (Inhibitor of Caspase-3-Activated DNase) regulates nuclear apoptosis by inhibiting CAD (Caspase-Activated DNase).
ICAD has two isoforms:
- ICAD-L/DFF45 (45 kDa): functional isoform
- ICAD-S/DFF35 (35 kDa): non-functional isoform
ICAD prevents CAD activation until cleaved by caspase-3 at residues 117 and 224, releasing CAD to execute apoptotic DNA fragmentation.
It also functions as a folding chaperone for CAD. ICAD is being studied as a potential target for restoring apoptotic signaling in colon and brain cancer cells.
Two alternatively spliced transcript variants encode these distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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