Thermo Fisher Scientific WWC1 Polyclonal Antibody
Rabbit polyclonal antibody against human WWC1 (KIBRA) protein. Recognizes recombinant WWC1 antigen. Useful for Hippo pathway and tumor suppression research. Supplied as a liquid, unconjugated form, concentration 0.3 mg/mL. For research use only.
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- PA558211
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Thermo Fisher Scientific WWC1 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human WWC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649670 |
Product Specific Information
Immunogen sequence:
RSGERSTRWY NLLSYKYLKK QSRELKPVGV MAPASGPAST DAVSALLEQT AVELEKRQEG RSSTQTLEDS WRYEETSENE
Antigen sequence identity:
- Mouse: 78%
- Rat: 79%
Target Information
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway, which plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis.
WWC1, along with NF2, can synergistically induce phosphorylation of LATS1 and LATS2.
It acts as a transcriptional coactivator of ESR1, essential for DYNLL1-mediated ESR1 transactivation.
WWC1 also functions as a regulator of collagen-stimulated activation of the ERK/MAPK cascade.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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