Thermo Fisher Scientific WWC1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human WWC1. Recombinant protein control fragment (Product #RP-96836). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WWC1,uniProtId:Q8IX03-1,ncbiNodeId:9606,antigenRange:545-611,antigenLength:1113,antigenImageFileName:PA5-58212_WWC1_Q8IX03-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58212_WWC1_Q8IX03-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649671

Product Specific Information

Immunogen sequence: PPCSPLMADP LLAGDAFLNS LEFEDPELSA TLCELSLGNS AQERYRLEEP GTEGKQLGQA VNTAQGC

Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 76%.

Target Information

WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.