Thermo Fisher Scientific Mouse RIP3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids of mouse RIP3.
PEP-0081 can be used as a blocking peptide with polyclonal antibody PA5-19956.

Target Information

RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm and specifically colocalized in the mitochondrion, which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex and can induce apoptosis and weakly activate the NF-kappaB transcription factor. Caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR, and this complex is required for the protective function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.