Thermo Fisher Scientific TRPM4 Polyclonal Antibody
TRPM4 단백질을 인식하는 Thermo Fisher Scientific의 Sheep Polyclonal 항체입니다. Western blot과 IHC에 모두 사용 가능하며, Mouse와 Rat 시료에 반응합니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 보관할 수 있습니다.
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- OST00027W-100UL
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse TRPM4 conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPM4.
Target Information
TRPM4 is a calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization.
It is activated by intracellular Ca²⁺ but is impermeable to it.
Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to depolarization of the membrane.
Plays a central role in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, and cochlear hair cells.
Participates in T-cell activation by modulating Ca²⁺ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production.
Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells.
May also contribute to pacemaking or irregular electrical activity under Ca²⁺ overload conditions.
Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through regulation of calcium signaling and NFATC1 localization.
Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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