Thermo Fisher Scientific TRPM4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPM4.

Target Information

TRPM4 is a calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization.
It is activated by intracellular Ca²⁺ but is impermeable to it.
Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to depolarization of the membrane.
Plays a central role in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, and cochlear hair cells.
Participates in T-cell activation by modulating Ca²⁺ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production.
Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells.
May also contribute to pacemaking or irregular electrical activity under Ca²⁺ overload conditions.
Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through regulation of calcium signaling and NFATC1 localization.
Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.