Thermo Fisher Scientific CDKN2C Monoclonal Antibody (18P118 (DCS-118))

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50

View 1 publication 1 publication

Immunoprecipitation (IP)

1-2 µg/mL

-

Product Specifications

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

18P118 (DCS-118)

Immunogen

Purified recombinant p18INK4c protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980316

Product Specific Information

MA5-14282 targets p18INK4c in IF, IHC (P), IP, and WB applications and shows reactivity with Human and mouse samples.

The MA5-14282 immunogen is purified recombinant p18INK4c protein.

Target Information

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.