Thermo Fisher Scientific Btk Polyclonal Antibody
Rabbit polyclonal antibody targeting human Bruton tyrosine kinase (BTK). Validated for WB, IHC(P), and ICC/IF applications. High predicted cross-reactivity with multiple species. Supplied as unconjugated liquid form with 0.62 mg/mL concentration....
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| Item | Description |
|---|---|
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 429–659 of human BTK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.62 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544868 |
Product Specific Information
- Recommended positive control: Molt-4
- Predicted reactivity: Mouse (99%), Rat (98%), Pig (99%), Chicken (86%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily. Mutations in the BTK gene are associated with developmental blocks in B-cell ontogeny and immunodeficiency disorders. BTK interacts with members of the toll-like receptor (TLR) family, including TLR4, 6, 8, and 9, which play key roles in innate and adaptive immunity. It also interacts with proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting its involvement in lipopolysaccharide signaling.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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(이미지 파일명: PA5-27392_BTK_Q06187-1_Rabbit.svg / PA5-27392_BTK_Q06187-1_Rabbit_PDP.jpeg)
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