Thermo Fisher Scientific Ataxin 3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:20,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, HeLa, HepG2, SK-N-SH, SK-N-AS, human Ataxin3-transfected 293T
• Predicted reactivity: Mouse (88%), Rat (82%), Pig (89%), Sheep (92%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Machado-Joseph disease (MJD) is an autosomal dominant neurologic disorder, also known as spinocerebellar ataxia-3. The MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region; expansion from normal 13–36 to 68–79 causes the disease. There is a negative correlation between age of onset and CAG repeat numbers. Ataxin-3 interacts with transcription regulators (CBP, p300, PCAF), represses transcription, and acts as a histone-binding protein regulating transcription. MJD functions as a deubiquitinating enzyme.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.