Thermo Fisher Scientific AKAP8 Polyclonal Antibody
AKAP8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, ELISA 등에 적합하며 Human 및 Mouse 반응성. 고순도 Affinity Chromatography 정제 및 -20°C 보관.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 480–692 of human AKAP8 (NP_005849.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.08 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2914422 |
Product Specific Information
Positive test controls include: LO2, 293T, BxPC-3, HeLa, Jurkat, mouse thymus.
The target is usually found in the following locations: Nucleus matrix.
Immunogen sequence:
HCLACDMLIP AQPQLLQRHL HSVDHNHNRR LAAEQFKKTS LHVAKSVLNN RHIVKMLEKY LKGEDPFTSE TVDPEMEGDD NLGGEDKKET PEEVAADVLA EVITAAVRAV DGEGAPAPES SGEPAEDEGP TDTAEAGSDP QAEQLLEEQV PCGTAHEKGV PKARSEAAEA GNGAETMAAE AESAQTRVAP APAAADAEVE QTDAESKDAV PTE
Target Information
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by compartmentalization of the kinase to specific sites within the cell. To maintain this localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins, designated A-kinase anchoring proteins (AKAP).
AKAP95 (AKAP8) is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney, and skeletal muscle. During mitosis, AKAP95 is recruited to chromosomes and plays an essential role in mitotic progression. It participates in PKA signaling through interaction with the RII regulatory subunit and forms a complex with HA95 and HDAC3, required for deacetylation of Histone H3 in mitosis.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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