Thermo Fisher Scientific Phospho-SMO Receptor (Ser594, Thr597, Ser599) Polyclonal Antibody
SMO 수용체의 Ser594, Thr597, Ser599 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from mouse SMO around the phosphorylation site of Ser594/Thr597/Ser599. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 amino acids. It has seven transmembrane domains, four glycosylation sites, and a putative extracellular amino terminus. Smoothened, activated by β-Arrestin 2 and GRK2, acts as a receptor for Sonic hedgehog (Shh) and is a positive regulator of the Hedgehog signaling pathway along with the patched protein (PTCH). It regulates vertebrate development, cellular proliferation, and differentiation via activation of transcription factor Gli. Mutations in Smoothened are associated with sporadic basal cell carcinoma of the skin. It is widely expressed in heart and brain tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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