Thermo Fisher Scientific PDPK1 Polyclonal Antibody
Thermo Fisher Scientific의 PDPK1 Polyclonal Antibody는 Rat, Human, Mouse에 반응하며 Western blot, IHC, ELISA에 사용 가능. Rabbit IgG 기반의 비결합 액상 항체로, 높은 순도와 안정성을 제공. PDPK1 관련 신호전달 및 대사 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 409–556 of human PDK1/PDPK1 (NP_002604.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.08 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914043 |
Product Specific Information
- Positive test controls: HCT116, Mouse brain, Rat brain
- Target localization: Cell junction, Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein, Focal adhesion
Immunogen sequence:
GSNIEQYIHD LDSNSFELDL QFSEDEKRLL LEKQAGGNPW HQFVENNLIL KMGPVDKRKG LFARRRQLLL TEGPHLYYVD PVNKVLKGEI PWSQELRPEA KNFKTFFVHT PNRTYYLMDP SGNAHKWCRK IQEVWRQRYQ SHPDAAVQ
Target Information
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to activation of glycogen synthase and stimulation of glycogen synthesis.
Because of its role in insulin-induced glycogen synthesis and PKC activation, PDPK1 is an important target for metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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