Thermo Fisher Scientific TSPO Polyclonal Antibody
TSPO 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고품질 항체로 인간 시료 반응성 확인. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PBR. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2736329 |
Product Specific Information
- Positive Control: HeLa, U87-MG, A431
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, mediating cholesterol delivery to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation.
PBR is composed of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier.
It is genetically conserved from bacteria to humans and widely expressed in peripheral organs, with limited expression in the brain, mainly in glial cells.
Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into mitochondria, and subsequent steroid formation.
A cytoplasmic protein, PRAX-1 (peripheral benzodiazepine receptor-associated protein 1), specifically interacts with PBR.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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