Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI4E2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

T-cell activation is regulated through inhibitory receptors such as PD-1 (also known as PDCD-1), which binds ligands PD-L1 and PD-L2 on antigen-presenting cells (APCs). Upon ligand binding, PD-1 transmits inhibitory signals that downregulate immune responses in the absence of danger signals (e.g., LPS).
PD-1 deficiency in mice leads to hyperactivated immune systems and autoimmune diseases.
Although PD-1 has a predicted molecular weight, it often migrates at a higher apparent molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.