Thermo Fisher Scientific Neurogenin 1 Polyclonal Antibody
Neurogenin 1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 ELISA에 적합하며, 신경발생 관련 연구에 활용됩니다. 액상형, Affinity Chromatography 정제, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–237 of human NEUROG1 (Q92886) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.28 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806332 |
Product Specific Information
- Positive Samples: SH-SY5Y, THP-1, U-87MG, HepG2, Mouse testis
- Cellular Location: Nucleus
Immunogen sequence:
MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
Target Information
Neurogenin 1 (NeuroG1)는 basic helix-loop-helix (bHLH) 전사인자로, 세포 발달 중 세포 유형을 결정하는 역할을 합니다. NeuroG1은 신경발생(neurogenesis) 과정에서 전사 활성자로 작용하며, 신경줄기세포가 성상세포로 분화되는 것을 억제합니다. 또한 CREB-binding protein 복합체의 위치 조절을 통해 astrocyte 관련 유전자의 발현을 억제하고, gliogenesis에 필요한 STAT 전사인자를 저해합니다.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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