Thermo Fisher Scientific OPRL1 Polyclonal Antibody
Thermo Fisher Scientific의 OPRL1 Polyclonal Antibody는 인간 OPRL1 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 ELISA에 적합하며, 세포막 및 세포질 소포 위치 단백질 검출에 사용됩니다. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 보존 용액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 270–370 of human OPRL1 (NP_000904.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.54 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806334 |
Product Specific Information
- Positive Samples: K-562, SW620, NCI-H460, U-87MG
- Cellular Location: Cell membrane, Cytoplasmic vesicle, Multi-pass membrane protein
Immunogen sequence:
AVFVGCWTPV QVFVLAQGLG VQPSSETAVA ILRFCTALGY VNSCLNPILY AFLDENFKAC FRKFCCASAL RRDVQVSDRV RSIAKDVALA CKTSETVPRP A
Target Information
The G-protein-coupled receptor (GPCR) superfamily comprises approximately 600–1,000 members and represents the largest known class of molecular targets with therapeutic value.
The nociceptin receptor is a G-protein coupled opioid receptor acting as a receptor for the endogenous neuropeptide nociceptin. Ligand binding induces conformational changes that activate G protein-mediated signaling, inhibiting adenylate cyclase and calcium channel activities. Arrestins modulate these pathways and activate MAP kinase signaling.
This receptor plays roles in modulating nociception, pain perception, and locomotor activity regulation by nociceptin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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