Thermo Fisher Scientific OPRL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 270-370 of human OPRL1 (NP_000904.1) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OPRL1,uniProtId:P41146-1,ncbiNodeId:9606,antigenRange:270-370,antigenLength:370,antigenImageFileName:PA5-91935_OPRL1_P41146-1_Rabbit.svg,antigenImageFileNamePDP:PA5-91935_OPRL1_P41146-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.54 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806334

Product Specific Information

Positive Samples: K-562, SW620, NCI-H460, U-87MG; Cellular Location: Cell membrane, Cytoplasmic vesicle, Multi-pass membrane protein

Immunogen sequence: AVFVGCWTPV QVFVLAQGLG VQPSSETAVA ILRFCTALGY VNSCLNPILY AFLDENFKAC FRKFCCASAL RRDVQVSDRV RSIAKDVALA CKTSETVPRP A

Target Information

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.