Thermo Fisher Scientific TCF7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TCF1/TCF7 (NP_0031932) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TCF7,uniProtId:P36402-1,ncbiNodeId:9606,antigenRange:50-150,antigenLength:384,antigenImageFileName:PA5-91923_TCF7_P36402-1_Rabbit.svg,antigenImageFileNamePDP:PA5-91923_TCF7_P36402-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.95 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806328

Product Specific Information

Positive Samples: Mouse spleen; Cellular Location: Nucleus

Immunogen sequence: ELKSSLVNES EGAAGGAGIP GVPGAGAGAR GEAEALGREH AAQRLFPDKL PEPLEDGLKA PECTSGMYKE TVYSAFNLLM HYPPPSGAGQ HPQPQPPLHK A

Target Information

TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5-WWCAAAG-3) found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.