Thermo Fisher Scientific Trypsin 2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Trypsin 2,uniProtId:P07478-1,ncbiNodeId:9606,antigenRange:24-247,antigenLength:247,antigenImageFileName:PA5-121156_Trypsin_2_P07478-1_Rabbit.svg,antigenImageFileNamePDP:PA5-121156_Trypsin_2_P07478-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.37 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914728

Product Specific Information

Positive test controls include: Mouse spleen, Mouse skeletal muscle. The target is usually found in the following locations: Secreted, extracellular space.

Immunogen sequence: IVGGYICEEN SVPYQVSLNS GYHFCGGSLI SEQWVVSAGH CYKSRIQVRL GEHNIEVLEG NEQFINAAKI IRHPKYNSRT LDNDILLIKL SSPAVINSRV SAISLPTAPP AAGTESLISG WGNTLSSGAD YPDELQCLDA PVLSQAECEA SYPGKITNNM FCVGFLEGGK DSCQGDSGGP VVSNGELQGI VSWGYGCAQK NRPGVYTKVY NYVDWIKDTI AANS

Target Information

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.