Thermo Fisher Scientific Trypsin 2 Polyclonal Antibody
Rabbit polyclonal antibody against human Trypsin 2 (PRSS2). Validated for WB and ELISA. High specificity and affinity purified. Supplied in PBS with 50% glycerol, suitable for frozen storage at -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 24–247 of human PRSS2 (NP_002761.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.37 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914728 |
Product Specific Information
- Positive test controls: Mouse spleen, Mouse skeletal muscle
- Target localization: Secreted, extracellular space
Immunogen sequence:
IVGGYICEEN SVPYQVSLNS GYHFCGGSLI SEQWVVSAGH CYKSRIQVRL GEHNIEVLEG NEQFINAAKI IRHPKYNSRT LDNDILLIKL SSPAVINSRV SAISLPTAPP AAGTESLISG WGNTLSSGAD YPDELQCLDA PVLSQAECEA SYPGKITNNM FCVGFLEGGK DSCQGDSGGP VVSNGELQGI VSWGYGCAQK NRPGVYTKVY NYVDWIKDTI AANS
Target Information
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds following lysine or arginine residues. The protein is highly expressed in pancreatic juice and upregulated in pancreatitis. It can activate pro-urokinase in ovarian tumors, contributing to tumor invasion, and cleave type II collagen in rheumatoid arthritis tissue, potentially aiding cartilage matrix degradation. Alternative splicing produces multiple transcript variants.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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