Thermo Fisher Scientific BRSK1 Polyclonal Antibody
BRSK1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. Protein A로 정제된 1 mg/mL 액상 형태로, -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human BRSK1 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BRSK1 (also known as SAD1) is a serine/threonine kinase involved in UV-induced DNA damage checkpoint control. It is highly expressed in the brain and testes and plays a role in stress-induced cell cycle arrest. Overexpression leads to G2/M arrest in HeLa S2 cells, while reduced expression via siRNA partially abrogates UV-induced G2/M arrest, indicating its function in DNA damage checkpoint regulation.
BRSK1 and its related protein BRSK2 are essential for mammalian neuronal polarization. Double-knockout mice lacking both genes die shortly after birth, and their neurons show abnormal morphology with uniformly sized neurites expressing both axonal and dendritic markers. At least two isoforms of BRSK1 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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