Thermo Fisher Scientific AKAP13 Polyclonal Antibody
AKAP13 단백질을 인식하는 토끼 폴리클로날 항체로, IHC(P)에서 1:50~1:200 희석으로 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피 정제, 고순도(>95%), 4°C 단기 보관 및 -20°C 장기 보관 권장.
- 카탈로그번호
- PA536342
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 700–750 of human AKAP13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553481 |
Product Specific Information
- Detects endogenous AKAP13 protein (~307 kDa).
- Purity >95% by SDS-PAGE.
Target Information
A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that bind to the regulatory subunit of protein kinase A (PKA), anchoring the holoenzyme to specific cellular locations.
The AKAP13 gene encodes a member of this family and undergoes alternative splicing, producing multiple isoforms containing C-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains.
- DH domain: Involved in guanine nucleotide exchange activation for Rho/Rac GTPases, converting them to their active forms.
- PH domain: Functions in multiple signaling processes.
These isoforms act as scaffolding proteins coordinating Rho signaling pathways, anchoring PKA, and enhancing ligand-dependent activity of estrogen receptors α and β.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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