Thermo Fisher Scientific EXOSC10 Polyclonal Antibody
EXOSC10 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 실험에 사용 가능. 인체 유래 재조합 단백질을 면역원으로 제작. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PM-Scl. Recombinant protein control fragment (Product #RP-94454). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645698 |
Product Specific Information
Immunogen sequence:
KVTELEDKFD LLVDANDVIL ERVGILLDEA SGVNKNQQPV LPAGLQVPKT VVSSWNRKAA EYGKKAKSET FRLLHA
Ortholog sequence identity:
Mouse – 93%, Rat – 93%
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl.
Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients.
EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in the cytoplasm, supporting the existence of a nucleolar RNA exosome complex form.
As a putative catalytic component of the RNA exosome complex with 3’→5’ exoribonuclease activity, EXOSC10 participates in multiple cellular RNA processing and degradation events.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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