Thermo Fisher Scientific ITGB3BP Polyclonal Antibody
Human ITGB3BP 단백질에 특이적인 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충용액에 보관됩니다. 핵 수용체 및 전사 조절 연구용으로 적합한 고품질 연구용 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ITGB3BP (Product #RP-94264) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642813 |
Product Specific Information
Immunogen sequence:
KVEKLSEEIM EIMQNLSSIQ ALEGSRELEN LIGISCASHF LKREMQKTKE LMTKVNKQKL FEKSTGLPHK ASRHLDSYEF LKAI
Highest antigen sequence identity to the following orthologs:
- Mouse: 64%
- Rat: 60%
Target Information
ITGB3BP is a transcription coregulator that can act as both coactivator and corepressor. Isoform 1 is involved in coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent manner. It also functions as a transcriptional corepressor via interaction with the NFKB1 NF-kappa-B subunit, potentially interfering with its transactivation domain. ITGB3BP induces apoptosis in breast cancer cells through a caspase-2-mediated pathway involving mitochondrial membrane permeabilization. It may inhibit cyclin A-associated kinase and play a role in CENPA incorporation into centromeres through interaction with the CENPA-NAC complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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