Thermo Fisher Scientific FERMT3 Polyclonal Antibody, MaxPab
FERMT3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 시료에 반응하며 Western blot과 Immunocytochemistry에 적합. 액상 형태이며 PBS buffer에 보관. 혈소판 및 백혈구의 인테그린 활성화 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | FERMT3 (NP_113659.3, 1 a.a. ~ 663 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAGMKTASGD YIDSSWELRV FVGEEDPEAE SVTLRVTGES HIGGVLLKIV EQINRKQDWS DHAIWWEQKR QWLLQTHWTL DKYGILADAR LFFGPQHRPV ILRLPNRRAL RLRASFSQPL FQAVAAICRL LSIRHPEELS LLRAPEKKEK KKKEKEPEEE LYDLSKVVLA GGVAPALFRG MPAHFSDSAQ TEACYHMLSR PQPPPDPLLL QRLPRPSSLS DKTQLHSRWL DSSRCLMQQG IKAGDALWLR FKYYSFFDLD PKTDPVRLTQ LYEQARWDLL LEEIDCTEEE MMVFAALQYH INKLSQSGEV GEPAGTDPGL DDLDVALSNL EVKLEGSAPT DVLDSLTTIP ELKDHLRIFR PRKLTLKGYR QHWVVFKETT LSYYKSQDEA PGDPIQQLNL KGCEVVPDVN VSGQKFCIKL LVPSPEGMSE IYLRCQDEQQ YARWMAGCRL ASKGRTMADS SYTSEVQAIL AFLSLQRTGS GGPGNHPHGP DASAEGLNPY GLVAPRFQRK FKAKQLTPRI LEAHQNVAQL SLAEAQLRFI QAWQSLPDFG ISYVMVRFKG SRKDEILGIA NNRLIRIDLA VGDVVKTWRF SNMRQWNVNW DIRQVAIEFD EHINVAFSCV SASCRIVHEY IGGYIFLSTR ERARGEELDE DLFLQLTGGH EAF
Target Information
The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 play essential roles in integrin-mediated adhesion and spreading, while KINDLIN3 is restricted to hematopoietic cells and abundant in megakaryocytes and platelets. Several reports describe transcriptional misregulation of KINDLINs in various cancers. KINDLIN3 is essential for platelet integrin activation and outside-in signaling, suggesting potential therapeutic applications in platelet and leukocyte integrin modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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