Thermo Fisher Scientific Cul3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Cullin 3 protein. Suitable for IHC and IHC (Paraffin) applications at 1:100–1:500 dilution. Affinity-purified, unconjugated, liquid form. Stored at 4°C; predicted cross-reactivity with multiple species.
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Thermo Fisher Scientific Cul3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 and 700 of human Cullin 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Rat, Zebrafish, X. laevis, X. tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea pig, Pig, and Panda
Target Information
Cullin 3 (CUL3) is a member of the human cullin family (CUL1, 2, 3, 4a, 4b, and 5), homologous to the S. cerevisiae cdc53 gene.
CUL1 forms a complex with p19 skp1 and F-box protein p45 skp2 to create a ubiquitin ligase that regulates proteolysis of G1 cell cycle proteins.
In contrast, CUL2 associates with an inactive transcriptional elongation complex (SIII) composed of Elongin C, Elongin B, and VHL; the function of this association remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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