Thermo Fisher Scientific Progesterone Receptor Polyclonal Antibody
Progesterone receptor를 인식하는 Rabbit Polyclonal Antibody로, Western Blot과 Immunocytochemistry에 적합. Mouse 시료에 반응하며, Affinity chromatography로 정제됨. PBS/sucrose buffer에 저장되며, -20°C에서 보관 권장. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Progesterone Receptor Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.2–1.0 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of mouse Progesterone Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689394 |
Product Specific Information
This target displays homology in the following species:
- Dog: 91%
- Guinea Pig: 91%
- Mouse: 100%
- Rat: 91%
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two main isoforms:
- Form A (94 kDa)
- Form B (120 kDa)
These isoforms arise from alternative translation initiation sites. PR-B is the transcriptionally active form responsible for activating genes related to endometrial maintenance, pregnancy support, and ovulation inhibition. PR-A differs from PR-B by a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, the progesterone receptor forms a multiprotein complex including heat shock proteins and immunophilins. Upon hormone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE) to activate transcription. A null mutation in the PGR gene results in pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.