Thermo Fisher Scientific FOXC1 Polyclonal Antibody

Thermo Fisher Scientific FOXC1 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Cow: 86%
• Dog: 86%
• Horse: 86%
• Human: 100%
• Mouse: 100%
• Rat: 100%
• Zebrafish: 100%

Target Information

FOXC1 belongs to the forkhead family of transcription factors characterized by a distinct DNA-binding forkhead domain. Although its specific function is not fully known, it regulates the FGF19-FGFR4-MAPK pathway to promote development and maintenance of anterior segment structures within the eye.
Mutations in this gene are associated with various ocular disorders, including:

• Glaucoma
• Iridogoniodysgenesis anomaly
• Peters anomaly (central corneal leukoma, absence of posterior corneal stroma and Descemet membrane)
• Axenfeld-Rieger anomaly (posterior corneal embryotoxon, iris adhesion to Schwalbe line, hypertelorism, malar bone hypoplasia, congenital absence of teeth, and mental retardation)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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