Thermo Fisher Scientific PTRF Polyclonal Antibody
Rabbit polyclonal antibody against PTRF for detection in human and mouse samples. Validated for Western blot applications. Supplied as a liquid, 1 mg/mL in PBS with 2% sucrose. For research use only.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested at 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of mouse PTRF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688364 |
Product Specific Information
This target displays homology in the following species:
- Cow: 85%
- Dog: 92%
- Horse: 92%
- Human: 90%
- Mouse: 100%
- Rabbit: 85%
- Rat: 92%
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3′ end of pre-rRNA transcripts, regulating rRNA transcription by promoting complex dissociation and polymerase I re-initiation. PTRF localizes to caveolae at the plasma membrane and plays a critical role in caveolae formation and stabilization of caveolins, translocating to the cytoplasm after insulin stimulation. It is also implicated in lipid metabolism and insulin-regulated gene expression. Mutations in this gene are associated with generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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