Thermo Fisher Scientific CTSW Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

Cathepsin W (lymphopain) and cathepsin F form a novel subgroup of cathepsin proteases, distinct from other human cathepsins. The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81–119 bp. Cathepsin W protein is expressed specifically in CD8+ T lymphocytes. Expression occurs during differentiation of thymocytes to CD8+ T lymphocytes, coinciding with cessation of CD4 receptor expression. In transfected Cos-7 and HeLa cells, cathepsin W localizes within the rough endoplasmic reticulum.

Cathepsin W features:

• Unique 21 amino acid peptide insertion between active site histidine and asparagine residues
• Distinctive 8-amino acid carboxy-terminal extension
• Extended loop structure in the β-sheet domain
• Additional disulfide bond
• Additional cysteine and S2 pocket residue
• May exist as a dimer with disulfide linkage between monomers

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.