Thermo Fisher Scientific CD31 Polyclonal Antibody
CD31(PECAM-1)을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응. WB, IHC, IHC(Paraffin)에 사용 가능. 고순도 항원 친화 크로마토그래피 정제 제품으로, HUVEC 양성 대조군 권장. 연구용으로만 사용.
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Thermo Fisher Scientific CD31 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:10,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 288–552 of Human CD31 (PECAM-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546642 |
Product Specific Information
- Recommended positive control: HUVEC
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor that regulates T cell and B cell signaling through immunoreceptor tyrosine-based inhibitory motifs (ITIMs). It is expressed ubiquitously within the vascular compartment, mainly at junctions between adjacent cells.
The N-terminal Ig-like domain mediates homophilic binding, important for cell-cell interactions.
CD31 plays roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis, making it a key regulatory molecule in the vascular system.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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