Thermo Fisher Scientific HSF2 Polyclonal Antibody
Thermo Fisher Scientific의 HSF2 Polyclonal Antibody는 Human, Mouse, Rat 시료에 반응하며, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 1 mg/mL 농도의 액상 형태이며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific HSF2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:50–1:200
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 400–450 of Human HSF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803181 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing heat shock genes. In eukaryotes, this gene expression is regulated at the transcription level. Heat shock transcription factors (HSF1 and HSF2) are involved in this regulation.
HSF1 and HSF2 are upregulated by estrogen at both mRNA and protein levels. HSF1 normally exists as a monomer with repressed transcriptional activity via constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA-binding activity, and translocates to the nucleus.
HSF2 activity is associated with differentiation and development, and like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are induced by proteasome inhibitors of the ubiquitin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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