Thermo Fisher Scientific Survivin Polyclonal Antibody
Survivin 단백질을 표적하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, WB 및 IHC(P) 분석에 적합합니다. 인간에 반응하며, 암 및 세포주기 연구에 활용됩니다. 0.5 mg/mL 농도의 액상 시약으로 -20°C에서 보관합니다.
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Thermo Fisher Scientific Survivin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC(P)) | Assay-dependent |
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus amino acids CVRRAIEQLAAMD (aa 131–142) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2243412 |
Product Specific Information
- This antibody is predicted to react with bovine, canine, feline, and porcine based on sequence homology.
- Tested in Peptide ELISA with antibody detection limit dilution of 1:16,000.
Target Information
Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family.
IAPs are involved in cell signaling, division, metabolism, and are differentially expressed in most human cancers but not in normal tissues. Survivin contains a single BIR domain and lacks a C-terminus RING finger domain.
Gene expression is high during fetal development and in tumors but low in adult tissues. Survivin associates with microtubules during mitosis, regulating apoptosis and caspase-3 activity.
It is also expressed in brain tissues following traumatic injury, co-expressed with NeuN and PCNA, suggesting roles in neural cell proliferation.
At least four transcript variants encoding distinct isoforms have been identified, with three fully characterized. Survivin overexpression may bypass apoptotic checkpoints and promote tumor cell progression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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